Benefits From Using CBD
A study published in the Journal of Clinical Investigation and the National Institute of Health discovered that CBD can provide treatment for acne. Researchers used cannabis-derived cannabidiol on the human sebaceous glands and came to the conclusion that CBD acts as a highly effective sebostatic and anti-inflammatory agent by inhibiting lipid synthesis.
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Despite of the non-conclusive studies however, majority of the doctors consider the gained proof to be more than sufficient for starting the use of cannabidiol oil against prominent mood disorders such as social anxiety disorder.
It is to be kept in mind at all times that CBD oil contains anxiolytic properties which are highly beneficial for keeping the stress and anxiety at bay, but does not happen to be psychoactive. Therefore, if you have been looking for an answer to does CBD oil get you high, the good news is that it is different as compared to the other cannabinoids in being totally non psychoactive.
A group of 10 people was recruited for the study who have been diagnosed with social anxiety disorder in order to study the blood flow to a number of different parts of their brain.
Half the group was given CBD oil while the rest of the group was given a placebo. As per the results, the group with CBD medical treatment were seen to have a reduction in the anxiolytic features.
The blood flow to different parts of the brain did also hint towards a reduction in the anxiolytic features in patients with CBD medical treatment.
In the light of the information mentioned above, it can almost be taken for granted that CBD oil does have a proven outcome if utilized against social anxiety disorder.
Prion/Mad Cow Disease
Cannabidiol has been shown to halt prions, the proteins that cause neurodegenerative diseases like Creutzfeldt-Jakob disease and mad cow. The formation and accumulation of prions was prevented with the aide of cannabidiol during a study published in the Journal of Neuroscience in 2007. For mice that were infected, CBD increased their survival time by about a week.
Post Traumatic Stress Disorder
CBD is known to produce anti-anxiety and anti-inflammatory effects when ingested by slowing everything down and calming the user. Those with PTSD are often overcome with anxiety and stress, so patients frequently find relief by using cannabidiol. The antipsychotic benefits provide a stable mental environment for those that need it most.
In 2012, a group of German researchers published a study in the journal Translational Psychiatry. The potent antipsychotic Amisulpride and CBD were compared between 42 schizophrenia patients. The two treatments were deemed effective, but the short side-effect profile of CBD out shined the pharmaceutical option.
Some scientists say CBD could be an effective treatment for bowel diseases like Crohn's Disease. THC and CBD interact with the system that controls gut function in the body, something that Crohn's patients suffer issues with. The component of cannabis’ anti-inflammatory ability brings a lot of relief to those suffering from this condition.
Scientists at the Cajal Institute used animal models and cell cultures to find that CBD reversed inflammatory responses and served as durable protection from the effects of multiple sclerosis. Mice with 10 days of CBD treatment had superior motor skills and showed progression in their condition. Using this information, researchers concluded that CBD has the potential ability to reduce various aspects of MS.
How Cannabis Helps Endometriosis
Article by HM
Endometriosis occurs when the tissue that lines the inside of the uterus, called the endometrium, grows outside the uterus. Endometriosis impacts 10% of all women, a total of 176 million women worldwide. Symptoms can range from no pain at all, just infertility, pain and heavy bleeding only during menstrual periods and disabling pain 24/7. There is no cure and diagnosis may take up to a decade.
Endometriosis can be found growing in the ovaries, bowel or pelvis, but occasionally in the lungs, brain and other areas. Endometriosis sheds similarly to uterine lining, causing bleeding and pain in organs during the menstrual period. Severe endometriosis can cause adhesions and scar tissue; organs attach to each other or the spine, causing severe pain and reducing mobility permanently.
Many components of the Endocannabinoid System (ECS) are found in endometrial tissue and their levels are regulated by the menstrual cycle (in rodent models of the disease). These include cannabinoid receptors type 1 and type 2 (CB1 and CB2), N-acyl phosphatidylethanolamine phospholipase D (NAPE-PLD), an enzyme that synthesises endocannabinoids and fatty acid amide hydrolase (FAAH) an enzyme that breaks down endocannabinoids. The highest concentration of the endocannabinioid anandamide (AEA, the ‘bliss’ molecule) in the reproductive system is found in the uterus.
Endometriosis is linked to Endocannabinoid Deficiency (ECD). Women with endometriosis have lower levels of CB1 receptors in endometrial tissue. Reduced ECS function leads to the spread of endometriosis throughout the body and increased pain. Endometriosis pain is mediated through CB1 receptors. Human endometriosis cells proliferated (divided and grew) less when stimulated with a synthetic cannabinoid called WIN 55212-2. Rodent studies of endometriosis found animals had more pain when treated with AM251, a drug that inhibits the cannabinoid receptors and less pain when treated with WIN 55212-2.
Environmental toxins such as dioxin have been linked to ECD. Dioxin decreases levels of CB1 in endometrial tissue. As we are subjected to pollution in our air, water, grass and food as well as BPA in water bottles and receipts, it’s no wonder so many women in developed countries now have severe endometriosis. In the future we are certain more toxins will be linked to endometriosis risk as well as ECD.
Hormonal treatments for endometriosis carry certain risks, such as deep vein thrombosis (DVT’s) which are blood clots in the legs that can travel to the lungs and can kill. Dr Michele Ross, co-founded GreenStone Labs in May 2013 to bring new Cannabis technologies to market. Dr Ross has endometriosis and had used hormonal birth control and Lupron to manage her symptoms. She was hospitalised for lung blood clots which almost killed her. She hopes cannabinoid products will help other women avoid the same life-threatening condition, which feels like a heart attack and stops your ability to breathe.
It is very important that women with endometriosis on hormonal treatments do not smoke and this means Cannabis, too. Smoking increases the risk of deadly blood clots. If you prefer to inhale rather than eat your Cannabis, please vape. Vaporising Cannabis is better than smoking because it doesn’t burn the Cannabis. Smoking Cannabis releases toxins similar to cigarettes, can cause lung irritation and often disintegrates cannabinoids with healing properties. Vaporising Cannabis heats the air around the Cannabis, releasing a range of cannabinoids, each with unique health benefits.
Cannabis topicals, in the form of creams or lotions you put on your skin, can help with pelvic or back pain during the day.
Women with endometriosis are also encouraged to avoid chemicals in their food, hair and beauty products and environment, in addition to using Cannabis therapy. Go green!
Currently the only way to diagnose endometriosis is through a surgical procedure called a laparoscopy (often not covered by health insurance). Hence, diagnosis of endometriosis takes about a decade for the average woman. A simple biomarker of endometriosis, such as reduced endocannabinoids in blood or endometriosis tissue could save millions for the healthcare system and years of unnecessary pain for 176 million women suffering from the disease.
Mayo Clinic: Endometriosis, The molecular connections between the cannabinoid system and endometriosis (2012), Progesterone-dependent regulation of endometrial cannabinoid receptor type 1 (CB1-R) expression is disrupted in women with endometriosis and in isolated stromal cells exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (2012), Endocannabinoid involvement in endometriosis (2010), Antiproliferative effects of cannabinoid agonists on deep infiltrating
In a study using CBD, the development of diabetes in non-obese diabetic mice was prevented. Although there wasn’t a direct effect of cannabidiol on glucose levels, the treatment prevented the production of IL-12 by splenocytes. Preventing this cytokine is important because it plays a huge role in many autoimmune diseases.
Common treatments for fibromyalgia are anti-inflammatory medications, opioid pain medications and corticosteroids. A 2011 study that focused on CBD treatment for fibromyalgia produced very promising results for future uses in treatment. Half of the 56 participants used CBD, while the other half used traditional methods to treat their condition. Those that used cannabis saw a great reduction in their symptoms and pain, while those using traditional methods didn’t see much of an improvement.
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